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25/09/2008

法国音乐剧《巴黎圣母院》

http://www.tudou.com/playlist/id/974385/
这部在1998年首演的音乐剧,估计是李小葱最喜爱的音乐剧了,忍不住在这大吼一声。
 
这是一部融入了大量流行音乐元素的音乐剧,区别于一般传统音乐剧,它现代它摇滚它重旋律它情节性强,没有那么多的古典美声,每首歌都堪称经典流行,据说音乐作者用了20年去写它润色它,不知是真是假。它的配器用的是吉他贝司等,基本上没有交响乐的东西。可是这丝毫不影响它的感染力,华丽的音乐,炫目的舞蹈,主演性感的嗓音,首首经典!整部音乐剧有贯穿始终的主旋律,刚开始听就会发现音乐中有迷人的波西米亚风情。如果非要说什么不完美的话,李小葱觉得是整部剧最后部分的音乐(Esmeralda被抓到牢中后)让我感受到了一种恐慌与压迫,旋律开始有不确定性,主旋律被打破,舞蹈也越来越纷繁,没有很好的突出重点,而且悲剧的凄惨美木有了。但是但是瑕不掩瑜,它还是最好的音乐剧!
 
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这是原版的几位主演,现在都换人了,可是他们所演的版本在网上久久流传着,我脑中的印象也还是他们几个。
他们当时都是法国流行音乐界的当红歌手,诗人Gringoire演员是位著名的摇滚歌手,他的表演被广为称赞。神父Frollo则是李小葱最爱的!演的很好,成功的演出了内心的压抑,让我觉得他反而是最可悲最值得同情最值得爱的一个人,因为他痛苦最大他最爱Esmeralda吧,而他不能算一个坏人,他的那一切的手段,只不过是为了战胜自已忘掉Esmeralda而已。记得有一段是他看着Esmeralda在月下静坐梳头,神父独唱出对她的期待和内心的矛盾,音调越来越高,反映了灵魂中越来越大的痛苦挣扎,但是乐曲的终了又回归中音,显示热情又一次被压抑下来,因为他是一位副主教。金属的高音,磁性性感的中音与动作与眼神,演的天衣无缝!恕我词穷!我觉得这个角色是最需要演技的,后来的版本的演员长的太年轻,觉得他再演不出来原版那么好的了。
 
最喜欢的场景也是最著名的场景,《美人》(《Belle》),位于整部音乐剧的中场休息之前,是一场合唱,Esmeralda坐在场前端中间,先是Quasimodo吟诵Esmeralda的美貌与对她的向往,然后是Frollo演唱同一段,然后是Phoebus,同样的旋律,都唱得各有特色,最后是三个人合唱,Frollo唱低音合声。三个男主角分站在舞台的左中右,不同的歌词,显示他们对于Esmeralda爱的不同层次,Quasimodo是向往,Frollo是人性的弱点,Phoebus是大胆的情爱,意义不同,相同的是歌声中的那种撕心裂肺的爱的感觉。用心听他们唱,我也不经为他们感动叹息。

据说当初它首演时就震撼了整个欧洲艺术届,第一次就在巴黎就连演了126场,是法国有史以来最成功的音乐剧。而李小葱也是第一次看就被震了,是在五六年前在北大的日子,我至今都觉得它是最好的音乐剧,个人觉得比《猫》好很多,(猫的fans不要砸偶,我实在不喜欢猫的造型),比芝加哥(也很爱),红磨坊也要好。一个10年以前的音乐剧现在看来还是非常的现代流行,很难得。如今,它反复翻新换人场景越来越好,但是音乐不变,因为太完美了。永远珍藏着,不时翻出来,不时被感动。
22/08/2008

Closing Ceremony Viewing

olympic-poster-5

Acknowledgement for Olympic Games Viewing Event

 

We’d like to thank the following volunteers and organizations for their participation and contribution to this event. Thank you very much for your time and efforts!

 

Thank Cong Lucy Li, Xiaochun Mou, Peichang Shi, and Ahmed Youssef for brainstorming the project and draft the advertising letter

 

Thank Catherine Hoyt for grammar editing the advertising letter:

 

Thank Peichang Shi, Charles Voss, and Samia Husain for testing and setting up TV, VCR, karaoke

 

Thank Xingxing Chen for designing flyer

 

Thank Mew-bing Wan, Ahmed Youssef for ordering food

 

Thank Mew-bing Wan, Ahmed Youssef, and Fei Mao for setting up food

 

Thank Cong Lucy Li for designing the summary webpage after the event

 
Thank Yanjiao Xie, Guoqin Yu, and Chi Zhang for taking pictures from the event

 

Thank Xiaochun Mou, Qingqing Ye, and Jian He for making or getting exhibition boards

 

Thank Fei Yi, Xiaochun Mou for setting up exhibition boards

 

Thank Yifei Ding, Jenny Liu, Chi Zhang, Fei Mao, Yunfei Shi, Mew-bing Wan, Fei Yi, Li Zhao, Yang Li, and Xiaochun Mou for cleanning up

 

Thank Rongseng Wang, Yunfei Shi, Ujjwal Ramtekkar, Jialin Xu, Samia Husain, Guoqin Yu, Jue Huang, Fei Yi, Li Zhao, Yang Li, Yingyue Dai, Ningyuan Wang, Xiaohao Yu, and Xiaochun Mou for posting flyers

 

Thank CSSA (Chinese Students and Scholars Association) for its assistance in advertising

 

Thank IMUSE (Initiating Mutual Understanding through Student Exchange) for providing exhibition boards about China 

 

Thank I-CAN (International graduate students association for Career development And Networking) and GPC (Graduate Professional Council) for co-sponsoring this event.

28/07/2008

Olympics Viewing Event

Olympics Viewing Event

 

Still welcome volunteers for advertising! The more, the better! There is no requirement of how many flyers you have to post or forward, just try your best and have fun together! Your contribution are highly appreciated, and will be acknowledged on our official website. If you are interested, plz write to Lucy Li: cli@artsci.wustl.edu

 

The names below are the volunteers so far, thank you very much for your time and efforts!

 

Schedule

Time: 8/20 12:00-1:00pm (Men's Quarterfinal-basketball)

8/21 12:00-1:00pm (Women's 10m platform final)

        8/24 night (Closing Ceremony)

Location: Graduate Center -- the Danforth University Center Rm 300.

Check the website below for the exact venue.

http://danforthuniversitycenter.wustl.edu/flash.html

 

Volunteers

1. Record Olympic Games and turn on and off TV:

Volunteers: Peichang Shi and Samia Husain.

 

2. Design flyer:

Volunteers: Xingxing Chen;

 

3. Order food:

Volunteers: Mew-bing Wang, Ahmed Youssef.

 

4. Set up food:

Volunteers: Mew-bing Wang, Ahmed Youssef, and Fei Mao.

 

5. Design the summary webpage after the event:

Volunteer: Lucy Li.

 
6. Take pictures from the event:

Volunteers: Yanjiao Xie, Guoqin Yu, and Chi Zhang.

 

7. Make exhibition board:

Volunteers: Joanna Mou and Qingqing Ye.

 

8. Clean up:

Volunteers: Yifei Ding, Jenny Liu, Chi Zhang, Fei Mao, Yunfei Shi, Mew-bing Wang, Fei Yi, Li Zhao, Yang Li, and Joanna Mou.

 

9. Post flyers:

Volunteers: Rongseng Wang, Yunfei Shi, Ujjwal Ramtekkar, Jialin Xu, Samia Husain, Yunfei Shi, Guoqin Yu, Jue Huang, Fei Yi, Li Zhao, Yang Li, Yingyue Dai, Ningyuan Wang, Xiaohao Yu, and Joanna Mou.

 

Thank Cong Lucy Li, Xiaochun Joanna Mou, Peichang Shi, and Ahmed Youssef for brainstorming the project and drafting the letter. Thank Catherine Hoyt for revising the documents.

14/05/2008

转载自lemon

转载自lemon
Dear friends,
 
As you may know, a severe earthquake hit my home country in the afternoon of May 12th, 2008 (local time). Up to now, more than 12,000 people were killed and this number is keeping increasing... Townships were buried under landslides; schools and hospital buildings collapsed and thousands of students and patients were buried; millions of people got injured and lost their homes. The troop and emergency teams are exerting to rescue people that remain buried and injured, despite the heavy rain and disrupted traffic that hampered the rescue work greatly.
 
In case you want to donate to help the people there, some organizations that accept donations are listed below. Your generous support will assist the relief work, and help the people rebuild their lives.
 
1> American Red Cross has set up China Earthquake Fund. You can donate by phone (800-435-7669). Please indicate China Earthquake. Online donation is NOT available now.
2> Red Cross China accepts online donation using visa card. However their website is in Chinese. But you may also donate through Tsinghua Alumni (http://tsinghuafoundation.org/earthquake08/index.html). They accept PayPal and wired transfer and they will transfer the donations to Red Cross China promptly.
3> Hong Kong Red Cross also has China Earthquake Fund, and it accepted visa/mastercard donations(https://www.redcross.org.hk/donation/user_donation.asp).
 
I think 2> or 3> should be the most efficient ways but I am not sure whether they are tax exempt (probably not).
 
大家circulate出去吧。
国内现在都很难去到灾区,捐点钱也能有帮助!
10/03/2008

RSVP to the professional development workshop

 

Workshop Flyer

Insight into US Job Market and Culture

Are you designing your professional development in the early steps?
Do you know how US job market is different from your country's?
Do you know what US companies expect most of you?
Do you know what you need to improve besides your research ability?
Do you want to know the tips from successful alumni?

Come and join the workshop and discussion!

Date: 27th March, 2008
Time: 4:00pm-5:00pm
Location: Goldfarb Hall #132 on Danforth Campus
RSVP to the workshop: igspda@grad.wustl.edu


This workshop would start from an overview and guideline of job hunting to inspire a long term development plan to the junior students. Dr. Arlene Taich from the Career Center would talk about the multiple job choices, the approaches to get a job, the cases of successful alumni, and the cultural gap about the job market.

IGSPDA (International Graduate Student Professional Development Association) aims to improve the job marketability of the international graduate students. We are a group of passionate international students who have realized the difficulty in professional development for us. By interchanging information and ideas, we grow fast, become professional and excellent.

Join us if you are willing to learn, to try, and to work hard!


Sponsoring Group: IGSPDA & The Career Center

Fell free to distribute our flyer to interested students
http://foreverlucycurie.spaces.live.com/blog/cns!6B9302C41F36252!780.entry

For more information about IGSPDA, please visit
http://igspda.grad.wustl.edu/index.html

15/12/2007

墨菲定律

If there are two or more ways to do something, and one of those ways can result in a catastrophe, then someone will do it.
04/12/2007

HOME

两周之后的这个时候
我会在飞机上飞向我熟悉的一片土地

回家的感觉温暖着
那感觉到底是什么
记忆中,是大学里那个春天,当我遇到从没受过的委屈,自己慢慢的走向南门回家,两旁的绿油油的树缓缓退去,心里想着如何跟妈妈爸爸说这些事情,突然明白了,就算世界都辜负了我,我还是可以回家,那个永远不会因为我的成功或失败,任性或自负而抛弃我的地方。

家是那个有温柔善良可爱的妈妈的地方。至今我那可奈的老妈还没想明白为什么我从来没学过现在居然就会做饭。=P 妈妈已经把我的屋子清理了三遍,每天的email都在写等我回来给我做什么好吃的。
家是那个有睿智博学威严的爸爸的地方。来美国之后,给家里第一次打电话,爸爸说的第一句就是女儿我想你了,当时眼泪就滚滚的流下来了。之后,爸爸养起了小金鱼,他说家里太大太空了。每次打电话,老爸总能猜到是我打来的,第一句就是女儿,然后三句不离的就是我的安全。老爸,你可知道,女儿最担心的就是你的身体?女儿最爱的就是你。
家是那个透明清爽的地方,白天总是充满阳光,窗帘透过的光被风逗弄地摇曳。而我就在阳光下安静的看书学习,做着数学题物理题,看着报纸。等着爸爸妈妈回来。
家是那个夜里开一盏台灯,厨房里妈妈煲着汤,客厅里爸爸看着电视,安静的地方。心静的像黑夜一样纯粹。而现在,晚上我也只愿开台灯。而家就应该是那盏灯,无论是否点亮,都一定存在的地方。

当初,我以为我会哭着离开,结果却正相反。我笑着挥着手走进海关,而爸爸妈妈也都笑着。当时等待我的是一个挑战,一个憧憬,和一个梦想。家给我带来的是思念和奋斗,鼓励与支持,和向前冲不畏惧结果的勇气。回到家的时候,我一定不能流泪,因为我爱的人都在那里。我要告诉他们,有他们我一直不孤单,有他们我一直都坚强,有他们我一直都有信心。

828135702

20/11/2007

给blog拔草,转载个不相干的东西

嘿嘿,转载一个
百年不遇超级彗星大爆发 总体积已经超过太阳(组图)

一颗名为“霍尔姆斯”的彗星突然爆发,亮度增加了近百万倍,天文专家称这是百年不遇的彗星大爆发。最近半个月,您可在英仙座寻找这颗奇异彗星。该彗星的彗发与彗尾结构不明显,您可能会误以为它是一颗恒星

据《中国日报》报道上月底,“霍尔姆斯”彗星突然爆发,亮度增加了近百万倍。如今,这颗彗星亮度虽然变暗,但不断膨胀的“身体”让其体积超过了太阳。

1729

图为望远镜拍摄到的彗星“霍尔姆斯”(左)的照片,照片还提供了同比例的太阳(右)和土星(右下)图像以进行对比。

1720

这张照片是加拿大安大略省的业余天文爱好者拍摄的,显示了“霍尔姆斯”彗星在不同日期的位置。

太阳是太阳系中质量最大的天体,而相对渺小的“霍尔姆斯”彗星由于大爆发后不断释放气体和尘埃物质,使得其彗发(星云状的发光云体)已超过太阳的直径。夏威夷大学天文学家介绍说:“‘霍尔姆斯’如今已是太阳系中最大的单一物体。”

据夏威夷大学天文学家雷切尔·史蒂文森等人的测算,截至11月9日,“霍尔姆斯”的彗发直径达到869,900英里(140万公里),而太阳的直径约为864,900英里(139.2万公里)。

1726

业余天文爱好者11月1日拍摄的照片(左);照片显示“霍尔姆斯”的彗发由中心一层层尘埃物质和一条模糊的彗尾构成。哈勃天文望远镜11月4日拍摄到的照片(右)对“霍尔姆斯”彗星做了更为细致描写。这幅照片显示尘埃物质以水平偏转方向形成的蝴蝶结造型。

虽然“霍尔姆斯”在大爆发后,已开始变暗,但现在肉眼还可以依稀看到它的形状:黄昏后变成一个模糊的小点,高高挂在天空。这颗彗星从市区看有些模糊,不过换成是乡村则变得异常醒目。美国宇航局太空网天空观察栏目作者乔·拉奥说:“如今,在茫茫夜空中,它看上去是非常醒目的圆形云朵。”

据专业天文网站“太空气象”称,11月19日,“霍尔姆斯”的彗发将呈现透明状,届时将上演独一无二的天文奇观:“这颗彗星将从英仙座最亮的恒星‘天船三’身边滑过,像被吞噬似的,这绝对是不可错过的一幕。”

14/11/2007

狮子与太阳

恩恩恩,狮子座守护神是最多才多艺,最英俊最美,最阳刚的阿波罗,也就是光明之神--太阳了。
他的经典形象就是个大帅哥,一手拿着竖琴,一手拿着象征太阳的金球,驾驶着太阳战车。
 
今天连着几天阴沉的天空中终于露出一丝阳光
早上明晃晃的阳光洒在李小葱身上
眼睛中映满了透明的光泽
温暖温馨
整个心情豁然开朗
脚步也变轻松Smile
心想就算冬天一步步逼近
就算一场雨打落所有红红黄黄的树叶
短暂的阳光还是能带来愉悦
 
看来至少我这个狮子是不能缺少阳光滴~
赶明不会是要住热带去了吧。。。
 
好,继续倒计时回家
最好能在回家之前完成planned的实验
据说北京要下雪了
花花,我要通知你准备聚会鸟
我李小葱又回来啦!
好久木有见过你们了~
11/11/2007

11月11日

光光节,哦耶,散花~
单身比失恋幸福,老大如是教育我们,光光的筒子们共勉~
 
想念西门鸡翅了,回去一定要吃饱吃好,只有一个月就可以回去鸟~
23/10/2007

继续更新blog哈

写写qualify exam,前前后后痛苦煎熬了三个月,从五月份的动员会,到最后正式结束。当然要写写纪念一下。
 
painful,long-drawn, suspensive tortures。
一开始过于看重这个考试,又总觉得要求很高,所以洋洋洒洒地写了n个实验。再加上ambitiously选了个新而又新的题目,一共2周半的写文章的时间,结果悲剧发生于交稿前一周,有篇做差不多一样的paper发出来,全盘计划又打乱。最后一周超级赶的跟老师们讨论,把文章给糊弄出来了。
明知写的很烂,还是猪头地交了上去。几度生不如死的等结果(@¥#¥@*~**@!#&*&&。。)。最后是把实验cut掉了3/4,才安全的通过。
 
我就在想是不是自己承受压力的能力太差,后来才知道除了像luoshuo那样彪悍的人,大家都很suffer。
有的一周找心理医生四次,有的直接去喝酒,连美国学生都那样,像李小葱这样幼小心灵的小屁孩在快结束的时候有资格考试综合症,也算不太坏了。
尤其是我们的MSTP的同学们,其中一个成绩非常好的,居然被虐的差点家庭破裂了,在重考之前毅然决然的quit掉了,安安心心的回去读MD。大家都唏嘘不已,羡慕的居多,毕竟人家有选择的资本,就算不做science,照样能做很好,现在不enjoy做科学了,眼都不眨下地跟老板说了。他老板开始还劝他,最后被他说服了。美国学生的个性确实很强~
 
qualify过去了,现在又是RO1季节,让我意识到,grant proposal大改小改都是常事,reviewer喜不喜欢也只能吃斋念佛祷告看他们心情了~ 不要12%能pass,自己得个12.3%什么的fail掉,hoho~

可不可以不勇敢

失恋分手的歌总是写的很好。
最近st. Louis的天总是阴阴的,hoho,李小葱也没来由地低沉一把,恩恩。是不是晒不够太阳就容易depressed?有科学证据的吧。
筒子们,你们那边的天气如何亚?有没有阳光普照,万里无云的好地方捏?Take care~
 
可不可以不勇敢
范玮琪

你用浓浓的鼻音说一点也没事
反正又美又痛才是爱的本质
一个人旅行也许更有意思
和他真正结束才能重新开始
几年贴心的日子换分手两个字
你却严格只准自己哭一下子
看着你努力想微笑的样子
我的心像大雨将至那么潮湿
我们可不可以不勇敢?
当伤太重心太酸无力承担
就算现在女人很流行释然
好像什么困境都知道该怎么办
我们可不可以不勇敢?
当爱太累梦太乱没有答案
难道不能坦白的放声哭喊?
要从心底拿走一个人很痛很难
15/10/2007

色*戒

看完了色戒,发现自己想说的太多,却因为心情起伏,无法写出一篇有逻辑的东东。把最强烈的印象写下来吧。
 
朋友无法明白王佳芝,但是我理解,作为一个女生。
 
我感慨伟仔的演技,我想不出易先生别的样子,除了伟仔的表情留在我心中的印象。王佳芝临死的时候,一副平静而释放的表情,她确实解脱了。可惜易先生要比王佳芝坚强,所以当他下令杀王佳芝的时候注定他要承受更多心里的折磨。王佳芝生是他的人,死是他的鬼了。但这样的手段和决断也许让更多的人骂他了吧。可这才是一个特务头子。否则,王佳芝也不会被打动了。铁汉柔情,说的就是这种了。我也相信易先生最后是明白王佳芝的爱的,我宁愿,或者我希望易先生是明白的。这样易先生也不会太心碎。这部片子是冲着伟仔去的,最后也让我为他的痛而痛。演的非常成功,除了他没别人能演出来一个不让人痛恨的特务了吧。
 
我为李安喝彩。看过张爱玲的原著,短短的一个故事,看完也没有什么感触。反是这部电影,多了这些心理,这些肢体,人物立刻变得丰满起来。原著会让人很想痛扁王佳芝,电影让我感同身受的同情她。原著里结尾显得很没有逻辑和理由,可是电影却铺陈地如此的自然,结局中王佳芝颤抖的睫毛,就让人完全理解了结局。
 
我还是要赞汤唯。演的很好。虽然开始挺生硬,但是越演越好。拿她和章子怡来比较没什么意义,可是还是忍不住地想,小章是肯定演不了这个角色的,而汤也是演不了玉娇龙的。所以归到底,还是要赞导演,挑对了人。导演眼中看到了什么故事,有了对的人,就自然能演出来好的效果。但是不是每个导演都能找到对的演员,都能看到有深度的故事。或许汤唯演艺妓回忆录会比小章演的好很多?我觉得这部片子是李安的一个飞跃,比以前的任何一部都要好。心理描写越来越细腻。我也更感叹,李安能把女性的心理揣摩得这样到位。赞李安!
 
真的有太多要说了。一部片子给我的震撼如此之大,也觉得很奇妙。走出影院还记得伟仔抬起的泪眼婆娑,心理还是一阵阵冲击波。无论男生女生都赞不绝口的好片子!
 
这部片子不是在教育大家爱国,也不是希望世界和平。只是一个极端的爱情放在一个动荡的大环境中。这样扭曲的爱情可能哪个时代都存在吧,只是乱世赋予了这段爱情更多的色彩与戏剧性。
 
all in all,这片子很好,推荐!
10/10/2007

点名游戏

被小龟点了,hoho,开始自我曝光一下。。。

 
重复游戏规则:
1、被点到名字的要在自己的博客或者空间上写下答案,所有问题都要真实回答,并且要将这几个题目传给你的七个好朋友,通知对方“你被点名了”。2、这七个人要在博客或者空间上注明是在哪接到的题目,并且再将题目传给其他七个朋友,让游戏继续下去,不得回传,被点名的人将得到大家的祝福,并且所有美丽的愿望都会在不久以后得以实现。3、虽然不可以回点,但是你的朋友的朋友还是可能会点到你,如果有第二次,甚至第三次点到,那说明你将会是一个非常幸运和幸福的人。4、答完题后,删除掉一个你想删除的问题,增加一个你想问的问题,然后传给你朋友。
 
题目:
 
0. 现在对自己最重要的是什么?------- 工作学习。
1. 你觉得远距离的恋爱会有结果吗?如果是你你怎么做?------- 不会。
2. 在你眼里我是一个怎样的人?------- 聪明,独立,执着的小龟。
3. 你现在住在哪个城市,如果能够选择,你希望住在哪里?------- st. louis,北京。
4. 如果现在可以让你随心所欲去旅行,你想去哪?------- 欧洲!(小龟我们是不是考虑一下啥时候一块去得了) 
6. 最不喜欢什么类型的人?------- 不诚实的人。
7. 会不会做饭?你希望你的伴侣(未来的伴侣)会做饭吗?------- 会做饭。无所谓。
8. 如果看到自己最爱的人熟睡在你面前你会做什么?------- 看着他睡觉,睡醒的时候给他个吻,亲亲他的眼睛。
9. 如果你爱的人不爱你怎么办?------- 让他爱上我。
10. 你msn现用的“名称”是什么,有什么含义?------- lucy,木有什么含义,起源自小学三年级,所以再次申明,俺的名字存在很久了~连俺爹都叫俺lucy。
11. 你认为有爱无性和有性无爱哪个会更难以接受?------- 母鸡。
12. 你最怀念的一段时光是什么?------- 高中,当时觉得科学很伟大很奇妙,每天都在想新奇的事情,还把报纸上看到的科学新闻剪下来保留。现在的passion少了很多了。
13. 你最喜欢你伴侣的什么?如果没有,你希望你的伴侣具有什么品质?------- 木有。有才情,聪明,坚强,温柔。
14. 谈谈你最近在听的音乐?------- 拷贝过来就没有答。。。木有特定的音乐。 
15. 你会选择你爱的人还是爱你的人?------- 母鸡。
16. 你觉得自己哪方面性格特征对别人最有吸引力?------- 母鸡,母鸡,还是母鸡。
17. 最近最让你迷惘的事情是什么?------- 选lab。
19. 如果暗恋她(他),你敢说出口吗?------- 也re刘旸,“不是不敢,是不说”。我希望两个人的感情是自然吸引,已经过了冲动的年龄了。
20. 你觉得宽容是一项值得赞美的品质么?为什么?------ 是。严于律己,宽以待人。还有谦让。中国人的传统。
21. 你是个感性的人还是理性的人?------- both。
22. 当你对很重要的事情感到力不从心时,怎么处理?------- pause, think, and redo it.
23. 你认为怎么样才算幸福的生活?------- 有希望的生活。  
24. 你最喜欢吃的五种食物是什么?------- 火锅,烤鸭,湖南米粉,蔬菜,巧克力。
25. 最喜欢的一件物品。------- 总在变化中。
26. (删掉了一个问题,所以添加新的一个)你觉得在你的感情中,是你付出的多,还是你的爱人付出的多?------- 现在才看开了这个问题,两个人的付出不应该做减法,应该做加法。
 
最后,最后,点名~~ 介个不大好办呐,大家都怪忙滴,呵呵,xiaoqi,zhehao,yanan,wangrui,ant,gira,weiren。挑了有blog的筒子们,hoho,自己对号入座哈。
09/10/2007

让我们来8卦一下Mario R. Capecchi,娱乐精神继续发扬

来自
The Scientist 2004, 18(4):14
 
Mario R. Capecchi, 65, does not like recounting his early life. This Howard Hughes Medical Investigator, who won the Lasker Award and Kyoto Prize for determining how to eliminate or modify a gene from the murine genome through homologous recombination, prefers concentrating on the present. Considering his past, the preference is understandable.


Published   1 March 2004

How did you survive as a child?


Part luck, part [ly being] resourceful, you had to get food by stealing. I became fairly good with it.... Once you are operating in a particular area, and your cover is blown, then you move on.

What scars remain? What strengths did you gain?
The easiest way is not even to think about it. The strengths are self-reliance. There are different ways of doing science. What we like to do [at this lab] is do it all ourselves.... To me, it's important to go into a biological problem and then develop [the] technology to answer that question. That is going back to being self-reliant, to finding your own food and surviving.

When you're on your own, you spend a lot of time thinking. To go from step A to step B, I can concentrate on something, it doesn't matter what is going on in the world around me. ...Science is sort of a funny thing. On the one hand, you have to be fairly bold and think of new things, but what makes it work is the detail, and that requires a lot of concentration.

Define stress for you
I do everything at the last minute. Stress is having a grant due in two weeks and not having started it. I have piles of stuff; anything that is two months [off] just sits there. 哈哈Open-mouthed

How did you start studying Hox genes?
In the early 1990s, people were studying Drosophila and people were studying mammals and other organisms and each thought the genes were going to be unique. So the Hox genes were the first set of genes that [made] people realize we were all together in the same ballpark ... [they are] involved in practically everything.... We are following the proteins themselves. We use micro-arrays that use RNA as a base to follow the activity of multiple genes.

What is your research goal?
I'm envisioning [two projects] that will take about 20 years to unravel. One is how the nervous system is put together. ...We inactivated Hox b8; that gives you a phenotype that resembles obsessive-compulsive disorders.... A lot of these genes are expressed in the forebrain. In the embryo, the orders in which they appear on the chromosome [determines] where on the body [the Hox genes] are operating. In an adult...the Hox genes can be anywhere; a lot of them are expressed in the brain.

And two: In mammals, 99% of the genes are the same... How do you have the same genes [and] get a completely different [function]?

One of the reasons to stay with Hox is that you can look at any aspect of biology – in the development of organs, or how to put neurons together, or how circuits are made.

What are your favorite papers?
In science... you never look backward. Last year's literature, you don't even think about it... [One] paper that influenced others was the 1987 Cell on gene targeting.[1] But there is a 1982 paper that I sent to Cell, and they refused it... [It] outlined the technology of gene targeting. I was quite offended by that [refusal]... Open-mouthedThe 1982 paper shows that the machinery to do homologous recombination is present in all cells.[2]

What frightens you?
The more we delve into how we work; we learn how more complex we are.... I see that we are going to have to be working a long time, at least another 100 years. ...What frightens me is the desire for immediate gratification. If we try to appease that, we will sell short the whole system.
 
You recently made an interesting discovery
I hadn't seen a picture of the house [where I grew up], yet it was in my mind. Recently, I received a prize in Trento, near there. Mother had rented a house, north of the Dolomites [in the Alps]. So as part of this prize, they wanted a few pictures.... I found one of the house. It looks very similar to where I live now.

Do you plan to retire?
My wife says that I am going to die at the lab bench.
 
 
 
October 08, 2007
The Making of a Scientist
by Mario R. Capecchi
摘选一下哈

I hope that the title of this lecture, "The Making of a Scientist," is not misleading. I have no formula for generating creative scientists. To the contrary, my thesis will be that such a formula may not exist. My skepticism comes from a deep-rooted prejudice that creativity in science, or in any other discipline, may require the abrasive juxtaposition of unique sets of life experiences that are too complex to preorchestrate. It is in this spirit that I will share with you my own experiences as a tribute to such stochastic, chaotic influences. The only general interest of this story is that it exemplifies the antithesis of a nurturing environment, which all of us deeply want to believe is a conducive prerequisite for fostering thoughtful, creative human beings.

In the spring of 1941 the Gestapo and SS officers came to our home and arrested my mother. This is one of my earliest memories. Although I was only 3-1 /2, I sensed that I would not see her for many years. She was incarcerated as a political prisoner in Dachau, Germany...

My mother anticipated her arrest by the Gestapo. Prior to their arrival, she sold most of her possessions and gave the proceeds to in Italian peasant family in the Tyrol so that they could take care of me. I lived on their farm for one year. It was a very simple life.

For reasons that have never been clear to me, my mother's money ran out after one year and at age 4-1/2 I set off on my own. I headed south, sometimes living in the streets, sometimes joining gangs of other homeless children, sometimes living in orphanages and most of the time being hungry. My recollections of those four years are vivid but not continuous, rather like a series of snapshots. Some of them are brutal beyond description, others more palatable.

In the spring of 1945, Dachau was liberated by the American troops. My mother survived the concentration camp and set out to find me...As a reminder of her flair for the dramatic, she found me on my ninth birthday. I am sure this was by design. I did not recognize her. In five years, she had aged a lifetime. I was in a hospital when she found me. All of the children in this hospital were there for the same reason: malnutrition. The prospects for most of those children ever leaving that hospital were slim because they had no nourishing food. Our daily diet consisted of a bowl of chicory coffee and a small crust of old bread. I had been in that hospital in Reggio Emilia for approximately one year. Scores of beds lined the rooms and corridors of the hospital, one bed touching the next. There were no sheets or blankets. It was easier to clean without them. We lay naked on those stripped beds. Our symptoms were monotonously, the same. In the morning we awoke fairly lucid. The nurse, Sister Maria, would take our temperature. She promised me that, if I could go through one day without a high fever. I could leave the hospital. She knew that without any clothes I was not likely to run away. By late morning the high, burning fever would return and we would pass into oblivion.

The same day that my mother arrived, she bought me a complete set of clothes, a Tyrolean outfit complete with a small cap with a feather in it. I still have the hat. We went to Rome, where I had my first bath in six years, and then to Naples. My mother's younger brother, Edward, had sent her money for two boat tickets to America. I was expecting to see roads paved with gold in America. I found much more: an opportunity.

My mother and I lived with my Uncle Edward and his wife Sarah. Edward Ramberg, my mother's younger brother, was a brilliant physicist. Among his many contributions was his discovery of how to focus electrons, knowledge which he used to build the first electron microscope. His books on electron optics have been published in many languages, including Japanese. Another achievement of which he was less proud was being a principal contributor to the making of both black and white, and color televisions. While I grew up in his home, television was not allowed...Open-mouthed

Sarah and Edward took on the challenge of converting me into a productive human. This was a formidable task. I had received no formal education or training for living as a social being. Quakers do not believe in frills but rather in a life of service. My aunt and uncle taught by example. I was given few material goods but every opportunity to develop my mind and soul. What I made of myself was entirely up to me. The day after I arrived in America, I went to school. I started in third grade. I was a good, but not serious student in grade school and high school. I attended an excellent high school, a Quaker school north of Philadelphia, George School. The teachers were superb, caring, challenging and enthusiastic.

After Antioch, I set off for the "mecca" of molecular biology, Harvard University. I interviewed with Professor James D. Watson, of Watson and Crick fame, and asked him where I should do my graduate studies. His reply was curt and to the point: "You would be...crazy to go anywhere else." The simplicity of the message was very persuasive.

Professor James D. Watson had a profound influence on my career. He personified molecular biology and his students were its eager practitioners. His bravado encouraged self-confidence in those around him. His stark honesty made our quest for truth uncompromising. His sense of justice encouraged compassion. He taught us not to bother with small questions, for such pursuits were likely to produce small answers...

Doing science in Jim's laboratory was a blast. As a graduate student, I was provided with what appeared to be limitless resources. I could not be kept out of the lab. Ninety-hour weeks were common. We were cracking the genetic code, determining how proteins were synthesized and isolating the enzymatic machinery required for transcription. At this time, Walter Gilbert also was working in Jim's laboratory. He was a member of the physics department, but was bitten by the molecular biology bug. Jim and Wally complemented each other brilliantlyOpen-mouthed, because they approached science from very different perspectives. Jim was intuitive, Wally quantitative. As students, we received the benefits of both.

My entry into what was going to become the field of gene targeting started in 1977. I was experimenting with the use of extremely small glass needles to inject DNA directly into the nuclei of living cells. The needles were controlled by hydraulically driven micromanipulators and were directed into nuclei with the aid of a microscope. Using this experimental paradigm, I asked whether I could introduce a functional gene into cells by injecting the DNA directly into their nuclei. This procedure turned out to be extremely efficient. One in three cells received the DNA in functional form and went on to divide and stably pass the gene on to its daughter cells. The high efficiency of microinjection meant that it was now practical to use this technology to generate transgenic mice by the injection of DNA into one-cell zygotes which were then allowed to come to term as embryos in foster mothers...

An observation that I personally found fascinating from these early microinjection experiments was that when multiple copies of a DNA segment were injected into a cell, although they were integrated into a random location within the host chromosome, they were always present in head-to-tail concatemers. Such highly ordered concatemers could be generated in two ways: (1) By replication, for example by a rolling circle type mechanism; or (2) by homologous recombination. We were able to prove that the concatemers were generated by homologous recombination. The significance of this observation was its demonstration that mammalian cells contain an efficient machinery for mediating homologous recombination. At the time, this was a startling discovery, because it was always assumed that the function of homologous recombination in all organisms was to ensure broad dissemination of the parental genetic traits to their offspring by shuffling these traits in the germ cells. Finding evidence for this activity in mouse fibroblast cells implied that all cells, somatic as well as germ cells, were capable of mediating homologous recombination. The machinery in somatic cells appeared to be very efficient, since I could inject over one hundred copies of a DNA sequence into a cell nucleus and they were all neatly incorporated into a single ordered head-to-tail concatemer. I realized immediately that, if I could harness this machinery to carry out homologous recombination between a newly introduced DNA molecule of our choice and the same DNA sequence in the cell's chromosome, I would have the ability to mutate at will any specific gene in the living cell...

In 1980, I submitted an NIH grant application outlining experiments intended to test the feasibility of gene targeting in mammalian cells. This part of the grant was soundly rejected. In the opinion of the reviewers, the probability that the newly introduced DNA would ever find its matching sequence within the host genome was vanishingly small and, therefore, the experiments were not worthy of pursuit. Despite this rejection, I decided to forge ahead with these experiments using a paradigm that was capable of detecting gene targeting events at a very low frequency. Once we observed a gene targeting event, we could optimize the conditions to improve its efficiency. By 1984, we were confident that it was feasible to do gene targeting in cultured mammalian cells and I presented our work at a memorable symposium on homologous recombination held at the Cold Spring Harbor Laboratory. We resubmitted our grant application to the NIH. This time, the grant proposal was received with enthusiasm, and the new critique started with the words, "We are glad that you didn't follow our advice."好搞笑,这个老头也挺逗,哈哈哈哈Open-mouthed

I have taken you on a brief journey through my experiences. Looking back, I marvel at the resilience of the child. As I lay naked on that stripped bed so many years ago, my constant preoccupation was fixed on plotting an escape. In the absence of any apparent hope, the will to survive persists.

It is not clear whether those early childhood experiences contributed to whatever successes I have enjoyed or whether those achievements were attained in spite of those experiences. When dealing with human life, we cannot do the appropriate controls. Could such experiences have contributed to psychological factors such as self-reliance, self-confidence or ingenuity? I have always considered as a personal strength the ability to concentrate for long periods of time on a chosen topic at the exclusion of everything else that is going on around me. Is the ability to participate in such mental exercises learned from experiences of prolonged preoccupation?

What I have learned from my own experiences is that the genetic and environmental factors that contribute to such talents as creativity are too complex for us to currently predict. In the absence of such wisdom, our only course is to provide all of our children with ample opportunity to pursue their passions and their dreams. Our level of understanding of human development is too meager to allow us to foresee which of the children in our midst will be the next Beethoven, Modigliani or Martin Luther King.

ZZ自yanan

ZZ自yanan

The Nobel Prize in Physiology or Medicine 2007

The Nobel Assembly at Karolinska Institutet has today decided to award The Nobel Prize in Physiology or Medicine 2007 jointly to Mario R. Capecchi, Martin J. Evans and Oliver Smithies for  their discoveries of  'principles for introducing specific gene modifications in mice by the use of embryonic stem cells'
 
Capecchi and Smithies: Modification of genes by homologous recombination.
Evans: Embryonic stem cells-vehicles to the mouse germ line
Two ideas come together-homologous recombination in ES cells
 
Mario R. Capecchi, born 1937 in Italy, US citizen, PhD in Biophysics 1967, Harvard University, Cambridte, MA, USA. Howard Hughes Medical Institute Investigator and Distinguishes Professor of Human Genetics and Biology at the University of Utah, Salt Lake City, UT, USA.
 
Sir Martin J. Evans, born 1941 in Great Britain, British citizen, PhD in Anatomy and Embryology 1969, University College , London, UK. Director of the School of Biosciences and Professor of Mammalian Genetics, Cardiff Universtiy, UK.
 
Oliver Smithies, born 1925 in Great Britain, US citizen, PhD in Biochemistry 1951, Oxford University, UK. Excellence Professor of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC, USA.
01/10/2007

retreat归来

李小葱肥来鸟~~
刷blog,除荒草。。。
可惜了没去成中秋晚会

先上OZARKS Lake的图片,听老罗说每年都是在这里,classmates里有去过genetics的,Biochem, MCB的,大家都觉得相比较这个地方是风景很好的一个,地方很大,有山有水的~ 虽然食物还是一样的buffet和BBQ。。。options多,但是不精致
 
早上到了以后,就开始了讲座,吃了个chocolate蛋糕就坐了下来,都是postdoc和student的'data-blitz' talk, 尔尔,快睡着了。
终于等到了keynote speaker。也不怎么期待的,结果一开始就发现很有意思,dendritic development和plasticity。哈哈,居然做的是CPEB,我原来minigrant写的gene,而且她们又开始研究另一个mRNA binding蛋白,当当当,FMRP,俺的BS thesis 蛋白啊。恩恩恩,觉得研究的东西都是相互关联的。yanan 提到任何两个人都可以由少于6个人联系起来的理论,呵呵是不是生物研究里,任何两个gene都可以由少于n个gene联系起来呢? ^@^

keynote speaker完了,就是lunch。服了老美,吃来吃去就那么几种东西,太没创意了,一点都不精致。salad还能吃。之后,大家就一起去climbing,说到这个李小葱真是晕啊,我是第5个sign up的,一共10个名额。但是,但是,first year和faculty有priority。李小葱居然都是second year了!!5555 于是变成了第二个alternate。最终没能爬那个tower,沦为御用业余photographer。。。=_=b
狠狠的拍了Tim Holy(做olfaction的faculty)爬的时候费力的样子,哈哈,Mena 要post到website上去哦。

下午的data blitz还是催眠。。。于是跟J同学一起跑出去玩,hike来着,可惜木有看到应该有的water fall和骑马地。
回到湖边,自己慢慢地走,觉得心情好多了,拍拍照片,拍着湖边,拍着天空,拍着鱼儿,拍着幸福的人们,拍着自己的背影,拍着自己的青春。有些思念的存在是煎熬,让时间慢慢冲淡它吧。

dinner,好几个人跟我说下午的keynote speaker讲的很好,哭死。当时觉得那个speaker反正也是个system neuroscience guy跟我也没什么关系,所以跑出去玩。后来听说讲的很深入浅出,可惜鸟。难道错过的都是最好?就像错过的这次的中秋晚会。zhehao同学仿佛办的很赞呢~

晚上,poster session。今年心情又不同了。去年来的时候,谁都不认识,进来也听不大懂。这一次几乎都有了概念,聊的也很欢,才觉得收获多了好多。party时候放了今年的vedio,学生和老师一起joke现在的funding issue,太tm搞笑了。那么多coolcool的老板配合演出,比如Gina Story扮演街头女郎,Paul Taghert演流浪汉,连校长都客串了,油菜花啊,服了。然后还是beer game,赫然发现David Van Essen也在game 队伍中,玩的比学生还欢,于是狂汗。。。系主任真放的开啊~

n,就这些了。希望明年的时候还有心情去retreat。=)
26/09/2007

转自梳子jj blog

The talk from Iran's president at Columbia Univ.
我也着实pf了一把columbia和伊朗总统。顶住压力啊~
前面一段里,校长同学也真是不容易,要面面俱到啊。
 
 
哈哈,还有远在德国的卢立同学仿佛没有什么事情,在外的同学们都一定注意身体,不要熬夜(pia飞自己,自己就经常熬)。中秋快乐! :)